| Safety School |
| Saga of the Lost by Nick Curd, Alex Jones, Alli Mawhinney, Tony Mitton, Mike Snowden and Traci Whitehead |
| Salem |
| Salem 1692: The Purge |
| Salem Witch Trials |
| Sam & Max Hit the Afterlife by Alex Bradley and Dave Kapell |
| Sam and Max Hit the Afterlife |
| Same Bat Time, Same Bat Mitzvah by Lucian Kahn, art by Ezra Rose and some material by James Mendez Hodes |
| Sanctuary by Sean Broadley, Naomi Guyer and Stephanie Pegg |
| Sandman: Gods and Secrets |
| Sanguine |
| Sarabande by Jeppe Bergmann Hamming and Maria Bergmann Hamming |
| Sassy Pirate Wenches on the Island of Stern Viking Jarls |
| Saturday Morning Massacre |
| Saturday Night, Gay Bar by Alexis M. Bontemps |
| Save Some Light for Me |
| Save Your Breath by Penelope Ray and Meredith Mayes |
| Scale by Betsy Isaacson |
| Scapegoat |
| Scattering by Azalea Weisblat |
| Scheherazade by fona lloyd |
| Scholomance: Gifted Children by Betsy Isaacson and Nicholas Knapp |
| Screwed 2 by Rita Flaherty |
| Screwing the Crew |
| Second Annual Mad Science Awards by Dybbuk |
| Second Dawn by Benjamin Philip, Kristen McFadyen and Jamey Patten |
| Second Hand Spirit Animals |
| Second Hand Spirit Animals: Second Time's the Charm by Elisa Ford |
| Second Watch by James Bloodworth, Steve Hatherley, Alli Mawhinney, Ric Mawhinney and Laura Wood |
| Secrets of the Deep by Reuben Strom, Rowena Knill, Nikki Brown and Phillip Brown |
| Secrets of the Necronomicon |
| Seek/Find |
| Seeker's Regret by Michelle Burt |
| Self Reflections |
| Self-Reflections by Sarah Judd, Elisabeth Cohen, Kiara Vincent and Michael Von Korff |
| Sensory Deprivation: A Cthulhu Live LARP by Caroline Murphy |
| Sentinel Comics Issue #404: Lock Down by John 'Izzy' Isabella and Nick Knapp |
| Service by Shoshana Kessock |
| Seven Deadly Virtues |
| Sex, Drugs, and Rock & Roll by Jennifer Diewald |